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TB-500

Original price was: $100.00.Current price is: $75.00.

TB-500 (Thymosin Beta-4 Fragment) is a synthetic version of the naturally occurring 7-amino acid active region of Thymosin Beta-4. Studied primarily for its systemic regenerative effects, TB-500 is a focal point for Canadian research into cell migration, angiogenesis, and the regulation of actin polymerization. Its low molecular weight allows for high bioavailability and systemic distribution in various experimental models.

Fast Domestic Shipping: Dispatched from within Canada (No customs delays)
Purity: ≥99.0% (HPLC Tested)
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Actin sequestration and muscle/tendon repair
Stability: Optimized for cold-chain Canadian transit; store at -20°C

Category: Peptides

Description

TB-500 (Thymosin Beta-4 Analog)

TB-500 is a synthetic peptide that replicates the active site of Thymosin Beta-4 (Tβ4), a protein found in nearly all human and animal cells. While Tβ4 is a full-length 43-amino acid protein, TB-500 focuses on the specific 7-amino acid sequence (Ac-LKKTETQ) responsible for the molecule’s most significant regenerative properties.

In Canadian research contexts, TB-500 is distinguished by its systemic action. Unlike peptides that remain localized, TB-500 is investigated for its ability to travel through the circulatory system to locate and influence sites of cellular damage. Research focuses on its ability to upregulate actin—a vital protein for cell structure and movement—making it a cornerstone for studies on wound healing and musculoskeletal recovery.

Technical Specifications

Peptide Name: TB-500 (Thymosin Beta-4 Fragment)
Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
CAS Number: 885340-08-9
Molecular Formula: C38H68N10O14
Molar Mass: 889.02 g/mol
Purity: ≥99.0% (determined by HPLC)Appearance: White lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into TB-500 centers on its “systemic repair” signaling:

Actin Sequestration: TB-500 is studied for its role as a G-actin sequestering peptide. By regulating actin polymerization, it influences the cytoskeleton, which is essential for cell motility and the migration of repair cells to injury sites.
Angiogenesis and Endothelial Migration: Investigations suggest TB-500 promotes the growth of new blood vessels (angiogenesis) by stimulating endothelial cell migration and differentiation.
Reduced Fibrosis (Scar Tissue): Studies explore TB-500’s ability to modulate the inflammatory response and reduce the formation of myofibroblasts, potentially leading to higher-quality tissue repair with less scarring.
Musculoskeletal Flexibility: Research models often utilize TB-500 to study improvements in connective tissue flexibility and the reduction of inflammation in tendons and ligaments.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for long-term stability. TB-500 is highly stable in its freeze-dried state; keep away from direct UV light and moisture.
Reconstituted (Liquid): Once dissolved in a research solvent, the solution should be kept at 4°C (39°F) and utilized within 14 days for optimal stability. Avoid repeat freeze-thaw cycles of the liquid solution.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
At Flux Peptides, we provide the chemical verification necessary for precision research. Every batch of TB-500 undergoes:

1. HPLC (High-Performance Liquid Chromatography): To confirm a purity profile of ≥99.0%.
2. MS (Mass Spectrometry): To verify the molecular identity of the Ac-LKKTETQ sequence.
3. Domestic Quality Check: Visual inspection and stability verification for the Canadian market.

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