SS-31 10mg

Description

SS-31 (Elamipretide) Overview

SS-31, also known in clinical literature as Elamipretide or Bendavia, is a member of the Szeto-Schiller (SS) peptide family. Unlike traditional antioxidants that indiscriminately scavenge free radicals across the entire cell, SS-31 is structurally engineered to bypass outer cellular barriers and accumulate directly on the inner mitochondrial membrane—the exact site where metabolic energy is produced and where oxidative damage originates. The primary research focus of SS-31 involves its interaction with cardiolipin, a phospholipid vital for the proper structure and function of the mitochondrial electron transport chain. By protecting cardiolipin from oxidation, SS-31 restores youthful mitochondrial respiration. It is heavily utilized in studies focused on age-related neurodegeneration, heart failure, and acute kidney injury.

Technical Specifications

• Peptide Name: SS-31
• Synonyms: Elamipretide, MTP-131, Bendavia, D-Arg-Dmt-Lys-Phe-NH2
• CAS Number: 736992-21-5
• Molecular Formula: C32H49N9O5
• Molar Mass: ~639.8 g/mol
• Purity: ≥99.0% (determined by HPLC)
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into SS-31 highlights its highly targeted bioenergetic rescue capabilities:

• Cardiolipin Binding: Selectively binds to cardiolipin on the inner mitochondrial membrane, stabilizing its structure and preventing the leakage of electrons during respiration.
• Targeted ROS Reduction: By optimizing the electron transport chain, it fundamentally stops the excessive production of reactive oxygen species (ROS) at their primary source, rather than just masking the damage.
• ATP Restoration: Reverses mitochondrial uncoupling, dramatically increasing the efficiency of ATP (cellular energy) synthesis in metabolically stressed or aged tissues.

Storage and Handling

• Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months.
• Reconstituted (Liquid): Once dissolved, the solution should be kept continuously refrigerated at 4°C (39°F) and utilized within 21 days.
• Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of SS-31 10mg undergoes:

1. HPLC: To ensure purity profiles strictly exceed 99.0%.
2. MS (Mass Spectrometry): To verify the precise tetrapeptide structure and the inclusion of the synthetic Dmt (dimethyltyrosine) residue.
3. Stability Analysis: To guarantee bioactivity over the course of demanding in vitro and in vivo studies.