SLU-PP-332

$70.00

SLU-PP-332 is a novel, synthetic small molecule acting as a pan-estrogen-related receptor (ERR) agonist. Highly regarded as a groundbreaking “exercise mimetic,” it is extensively researched for its profound ability to enhance mitochondrial biogenesis, aggressively upregulate fatty acid oxidation, and increase endurance capacity in skeletal muscle—all without the need for physical exertion in animal models.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Estrogen-related receptors (ERRα, ERRβ, ERRγ)
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Exercise mimicry, mitochondrial function, and metabolic syndrome
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

SLU-PP-332 Overview

SLU-PP-332 represents a major leap in metabolic and longevity research. It acts as an agonist for the estrogen-related receptor (ERR) family, specifically targeting ERRα, ERRβ, and ERRγ. These receptors play a central role in sensing cellular energy demands and orchestrating the body’s response to endurance exercise. In laboratory environments, SLU-PP-332 “tricks” the skeletal muscle into a state of high energy expenditure. Research demonstrates that administering this compound causes test subjects to metabolize fatty acids instead of glucose, effectively increasing the proportion of oxidative type IIa muscle fibers. It is a primary focus for studies addressing obesity, age-related sarcopenia, and metabolic decline where traditional exercise is impossible.

Technical Specifications

Molecule Name: SLU-PP-332
Synonyms: ERR Pan-Agonist
CAS Number: 2226257-27-0
Molecular Formula: C20H15F3N2O2
Molar Mass: 372.34 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in DMSO; partially soluble in bacteriostatic water (research specific buffers may be required)

Mechanism of Action (Research Context)
Research into SLU-PP-332 focuses on its direct modulation of deep cellular energy grids:

Pan-ERR Agonism: Directly binds to and activates the ERR triad, bypassing the need for physical muscle contraction to initiate the exercise-response signaling cascade.
Mitochondrial Biogenesis: Stimulates the creation of new mitochondria within skeletal muscle tissue, drastically raising the basal metabolic rate.
Fatty Acid Oxidation: Reprograms cellular metabolism to preferentially oxidize stored lipids for ATP production rather than relying on circulating carbohydrates, significantly reducing overall fat mass.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Protect from direct light.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 14-21 days for optimal experimental stability.
Handling: Standard laboratory safety protocols apply. Always wear protective gloves and eyewear. This product is for laboratory research use only.

Testing and Quality Control
At Flux Peptides, every batch of SLU-PP-332 undergoes:

HPLC (High-Performance Liquid Chromatography): Ensuring purity profiles consistently exceed 99.0%.
MS (Mass Spectrometry): Verifying molecular weight and structural integrity.
Stability Analysis: Confirming the compound maintains its receptor affinity under controlled laboratory conditions.

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