Description
SLU-PP-332 Overview
SLU-PP-332 is a synthetic small molecule. It is not a peptide and contains no amino acids: it is an acylhydrazone built from 4-hydroxybenzohydrazide and 2-naphthaldehyde, indexed by PubChem and by FDA GSRS as 4-hydroxy-N’-[(E)-naphthalen-2-ylmethylidene]benzohydrazide.
It acts as an agonist at the estrogen-related receptor family, with activity reported at ERR alpha, ERR beta and ERR gamma, which is why it is described in the literature as a pan-ERR agonist. These orphan nuclear receptors are studied for their role in transcriptional programmes governing mitochondrial biogenesis and oxidative metabolism. Published work on SLU-PP-332 is in cell systems and in rodents; it has not been studied in humans and it is not an approved medicine in Canada or the United States.
Technical Specifications
- Compound Name: SLU-PP-332 (a synthetic small molecule)
- Chemical Name: 4-hydroxy-N’-[(E)-naphthalen-2-ylmethylidene]benzohydrazide
- Synonyms: ERR pan-agonist 332, SR9861, 4-hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide
- CAS Number: 303760-60-3
- UNII: 5YW57G7ADL
- Molecular Formula: C18H14N2O2
- Molar Mass: 290.32 g/mol (monoisotopic exact mass 290.106)
- Purity: ≥99.0% (determined by HPLC)
- Appearance: White to off-white powder
- Solubility: Soluble in DMSO. Aqueous solubility is limited and research buffers may be required.
Mechanism of Action (Research Context)
The findings below come from the published literature, not from testing of this product, and the evidence level is stated for each:
- Pan-ERR Agonism: SLU-PP-332 binds and activates ERR alpha, ERR beta and ERR gamma. Because these receptors have no known natural ligand, a synthetic agonist is a research tool for studying what ERR activation does to gene transcription.
- Skeletal Muscle and Exercise Response (mouse): The 2023 paper that introduced the compound reported that it induced an ERR alpha dependent acute aerobic exercise gene response and increased running capacity in mice. This was measured in mice, not in people.
- Metabolic Measures (mouse): A 2024 pharmacology paper reported effects on markers of metabolic syndrome in a mouse model. A separate 2023 study reported changes in mitochondrial function and inflammation markers in aging mouse kidney. These are animal findings and have not been replicated in humans.
Storage and Handling
- Powder: Store at minus 20 degrees Celsius, sealed and protected from light and moisture; see the batch documentation for the retest date.
- In Solution: Keep stock solutions at 4 degrees Celsius or lower and protected from light, and treat them as suitable for experimental work for up to 14 to 21 days.
- Handling: Standard laboratory safety practice applies. Wear protective gloves and eyewear. DMSO stock solutions carry their own handling requirements.
Testing and Quality Control
Every batch of SLU-PP-332 is checked by:
- HPLC (High-Performance Liquid Chromatography): to confirm the purity profile against the ≥99.0% specification.
- MS (Mass Spectrometry): to confirm the molecular weight and chemical identity.
For laboratory research use only. Not for human or veterinary use.
Further reading
