Semax 11mg

$70.00

Semax 11mg is a highly researched synthetic heptapeptide acting as an analog of the adrenocorticotropic hormone (ACTH 4-10) fragment. Extensively utilized in neuropharmacology, it is currently at the forefront of nootropic and neuroprotective research. Studies focus heavily on its profound ability to upregulate Brain-Derived Neurotrophic Factor (BDNF), enhance cognitive function, and protect neurons from hypoxic and ischemic damage in mammalian models.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Melanocortin receptors and TrkB (via BDNF signaling)
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Neuroplasticity, cognitive enhancement, and ischemic neuroprotection
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

Semax Overview

Semax is a groundbreaking synthetic peptide originally developed by the Institute of Molecular Genetics at the Russian Academy of Sciences. It is engineered by combining a fragment of ACTH (adrenocorticotropic hormone) with a Prolyl-Glycyl-Proline (Pro-Gly-Pro) tripeptide sequence. This structural modification vastly increases its resistance to enzymatic degradation while completely stripping it of the hormonal, cortisol-elevating activity associated with full-length ACTH. In laboratory environments, Semax is primarily investigated for its pronounced neurogenic and neurorestorative properties. The 11mg bulk format is ideal for extended in vivo studies observing memory formation, learning acquisition, and the recovery of central nervous system (CNS) tissue following acute hypoxic events (oxygen deprivation).

Technical Specifications

Peptide Name: Semax
Synonyms: ACTH(4-10) Pro-Gly-Pro, Heptapeptide Semax
CAS Number: 80714-61-0
Molecular Formula: C39H54N10O10
Molar Mass: ~814.9 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in bacteriostatic water or sterile saline

Mechanism of Action (Research Context)
Research into Semax focuses on its multifaceted interactions within the central nervous system:

BDNF Upregulation: Drastically increases the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the hippocampus, fundamentally driving neurogenesis and synaptic plasticity.
Enkephalin Breakdown Inhibition: Slows the enzymatic degradation of endogenous enkephalins (natural opioid peptides), contributing to its observed mood-modulating and stress-buffering effects.
Dopaminergic & Serotonergic Modulation: Acts on neurotransmitter systems to enhance attention, focus, and the consolidation of short-term memory into long-term storage during laboratory behavioral assays.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Protect from direct light and ambient humidity.
Reconstituted (Liquid): Once dissolved, the solution should be kept continuously refrigerated at 4°C (39°F) and utilized within 14-21 days to prevent degradation.
Handling: Standard laboratory safety protocols apply. Always wear protective gloves and eyewear. This product is for laboratory research use only.

Testing and Quality Control
At Flux Peptides, every batch of Semax 11mg undergoes:

HPLC (High-Performance Liquid Chromatography): Ensuring purity profiles consistently exceed 99.0%.
MS (Mass Spectrometry): Verifying the precise 7-amino acid sequence.
Stability Analysis: Confirming the peptide maintains its neuroactive properties under controlled laboratory conditions.

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