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Semax 11mg research peptide vial

Semax 11mg

$70.00

Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, carrying a C-terminal Pro-Gly-Pro extension in place of the fragment’s final residues. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied mainly in animal models and in Russian clinical research. Semax is used clinically in Russia. It is not approved by Health Canada or the United States Food and Drug Administration. This 11mg format is supplied for laboratory research use only.

  • Purity: ≥99.0% (HPLC Tested)
  • Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (7 residues)
  • Format: Lyophilized Powder for Laboratory Research
  • Key Research Focus: Neurotrophin gene expression and central nervous system models of hypoxia and ischemia
  • Storage: Store at minus 20 degrees Celsius, sealed and protected from light and moisture
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Description

Semax Overview

Semax is a synthetic peptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analogue of the ACTH(4-10) fragment of adrenocorticotropic hormone: the first four residues of that fragment (Met-Glu-His-Phe, that is ACTH(4-7)) are retained and a C-terminal Pro-Gly-Pro tripeptide takes the place of the remaining residues, giving the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro. Chemical databases index it under the name ACTH (4-7), Pro-Gly-Pro. The Pro-Gly-Pro extension is reported to slow enzymatic degradation of the peptide, and published work describes the ACTH(4-10) region as lacking the adrenal corticotropic activity of the full-length hormone.

Semax is used clinically in Russia, where it has been registered since the 1990s, and it is not approved as a medicine by Health Canada or the United States Food and Drug Administration. A search of the Health Canada Drug Product Database returns no authorized product under this name. The published evidence base is mainly animal work together with clinical research reported in Russian-language journals, and it has not been replicated in large trials outside Russia. The 11mg format suits laboratory studies of behaviour and of central nervous system tissue in models of oxygen deprivation.

Technical Specifications

  • Peptide Name: Semax
  • Synonyms: ACTH (4-7), Pro-Gly-Pro; Met-Glu-His-Phe-Pro-Gly-Pro
  • CAS Number: 80714-61-0
  • UNII: I5FAL2585H
  • Molecular Formula: C37H51N9O10S
  • Molar Mass: 813.92 g/mol (monoisotopic exact mass 813.348)
  • Chain Length: 7 amino acid residues
  • Purity: ≥99.0% (determined by HPLC)
  • Appearance: White to off-white lyophilized powder
  • Solubility: Soluble in bacteriostatic water or sterile saline

Mechanism of Action (Research Context)
The mechanism of Semax is not settled, and several pathways have been reported in separate studies. The findings below come from the published literature, not from testing of this product:

  • Neurotrophin Gene Expression: Changes in the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have been reported in rodent brain tissue after Semax administration.
  • Gene Expression in Rodent Ischemia Models: A genome-wide transcriptional study in a rat model of brain focal ischemia reported that Semax altered the expression of genes related to the immune and vascular systems.
  • Other Reported Pathways: Separate studies have examined effects on the enzymatic degradation of endogenous enkephalins, on dopaminergic and serotonergic signalling, and, in a 2025 mouse study, on the mu opioid receptor gene Oprm1. These lines of work are preliminary and are not established mechanisms.

Storage and Handling

  • Lyophilized (Powder): Store at minus 20 degrees Celsius, sealed and protected from light and moisture; see the batch documentation for the retest date.
  • In Solution: Once dissolved, keep the solution at 4 degrees Celsius and protected from light, and treat it as suitable for experimental work for up to 14 to 21 days.
  • Handling: Standard laboratory safety practice applies. Wear protective gloves and eyewear.

Testing and Quality Control
Every batch of Semax 11mg is checked by:

  1. HPLC (High-Performance Liquid Chromatography): to confirm the purity profile against the ≥99.0% specification.
  2. MS (Mass Spectrometry): to confirm the molecular weight and the identity of the 7 residue peptide.

For laboratory research use only. Not for human or veterinary use.

Further reading