PT-141 10mg

$50.00

PT-141 (Bremelanotide) is a highly potent synthetic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH). Unlike traditional vascular therapeutics, PT-141 operates directly on the central nervous system. This 10mg format is extensively researched for its unique capacity to stimulate melanocortin receptors, making it a primary focal point in studies targeting sexual dysfunction, arousal pathways, and libido regulation in both male and female animal models.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Melanocortin 4 Receptor (MC4R) and MC3R
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Hypoactive sexual desire disorder (HSDD), CNS arousal, and libido
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

PT-141 (Bremelanotide) Overview

PT-141, also known globally by its generic name Bremelanotide, is a synthetic cyclic heptapeptide. It was originally developed from the peptide Melanotan II (MT-II) during research into synthetic tanning agents. Researchers quickly identified that this specific metabolite exerted profound aphrodisiac effects without the primary melanogenesis (tanning) properties of its predecessor. In scientific and clinical research, PT-141 is distinguished by its unique mechanism of action. While traditional treatments for sexual dysfunction (such as PDE5 inhibitors like sildenafil) rely on altering peripheral vascular blood flow, PT-141 bypasses the vascular system entirely. Instead, it crosses the blood-brain barrier to act directly on the central nervous system, driving neuroendocrine pathways related to sexual desire and arousal.

Technical Specifications

Peptide Name: PT-141 (Bremelanotide)
Synonyms: Bremelanotide Acetate, cyclo-[Nle4, Asp5, D-Phe7, Lys10]alpha-MSH-(4-10)
CAS Number: 189691-06-3
Molecular Formula: C50H68N14O10
Molar Mass: ~1025.2 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into PT-141 highlights its highly specific neuro-modulatory signaling:

MC4R Agonism: Acts as a potent non-selective agonist of the melanocortin receptors, specifically binding to the MC4R located in the hypothalamus, the brain’s control center for sexual behavior and autonomic function.
Dopaminergic Pathway Activation: The binding to MC4 receptors subsequently triggers the release of dopamine in the central nervous system, initiating the biochemical cascade responsible for sexual arousal and motivation.
Systemic Arousal: In animal models, administration reliably induces lordosis in females and erectile responses in males, irrespective of peripheral vascular limitations.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Avoid repeated freeze-thaw cycles.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 21 days for optimal experimental stability.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of PT-141 10mg undergoes:

HPLC: To ensure purity profiles strictly exceed 99.0%, removing any unwanted MT-II byproducts.
MS (Mass Spectrometry): To verify the exact cyclic structure and molecular weight.
Stability Analysis: To guarantee potency and structural integrity over the course of behavioral research studies.

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