L-Glutathione

$50.00

L-Glutathione is a potent, naturally occurring tripeptide comprised of glutamine, glycine, and cysteine. Widely recognized as the body’s “master antioxidant,” this compound is extensively utilized in cellular research to study its profound ability to neutralize reactive oxygen species (ROS), protect mitochondrial DNA from oxidative stress, and facilitate critical cellular detoxification pathways in laboratory models.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Glutathione peroxidase and Phase II detoxification enzymes
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Oxidative stress reduction, cellular longevity, and hepatic detoxification
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

L-Glutathione Overview

L-Glutathione (GSH) is a crucial endogenous tripeptide found in virtually every cell of mammalian organisms. It exists in two forms: reduced (GSH) and oxidized (GSSG). In research environments, the active, reduced form is heavily studied for its foundational role in maintaining cellular redox homeostasis. Because oxidative stress is a primary driver of cellular senescence and tissue damage, L-Glutathione is a focal point in anti-aging, neurodegenerative, and metabolic research. Laboratory studies frequently utilize L-Glutathione to observe the preservation of cellular integrity when exposed to environmental toxins, heavy metals, and induced oxidative damage.

Technical Specifications

Peptide Name: L-Glutathione (Reduced)
Synonyms: GSH, Gamma-L-glutamyl-L-cysteinylglycine
CAS Number: 70-18-8
Molecular Formula: C10H17N3O6S
Molar Mass: 307.32 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into L-Glutathione centers on its ubiquitous cytoprotective pathways:

ROS Neutralization: Directly donates an electron to neutralize free radicals and reactive oxygen species, preventing severe lipid peroxidation and DNA damage.
Mitochondrial Protection: Preserves the integrity of the mitochondrial membrane, ensuring sustained ATP (energy) production during periods of acute cellular stress.
Enzyme Cofactor: Acts as an essential cofactor for glutathione peroxidase, an enzyme complex critical for dismantling harmful hydrogen peroxide lipid peroxides into water and oxygen.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Protect from direct light.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 14-21 days to prevent natural oxidation back into the inactive GSSG form.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
At Flux Peptides, every batch of L-Glutathione undergoes:

HPLC (High-Performance Liquid Chromatography): Ensuring purity profiles consistently exceed 99.0% and confirming the active, reduced state.
MS (Mass Spectrometry): Verifying the precise tripeptide structure.
Stability Analysis: Confirming the compound maintains its antioxidant capacity under experimental conditions.

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