5-Amino-1MQ

$40.00

5-Amino-1MQ is a highly selective, membrane-permeable small molecule inhibitor of Nicotinamide N-methyltransferase (NNMT). It is at the forefront of metabolic and longevity research, heavily studied for its ability to prevent NAD+ depletion, combat diet-induced obesity, and regulate cellular energy expenditure without acting as a central nervous system stimulant.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: NNMT Enzyme Inhibitor
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Adipogenesis reduction, NAD+ salvage pathway, and metabolic efficiency
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

5-Amino-1MQ Overview

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a synthetic small molecule acting as a potent, selective inhibitor of the Nicotinamide N-methyltransferase (NNMT) enzyme. NNMT is heavily expressed in white adipose tissue and the liver, playing a critical role in energy balance by methylating nicotinamide (NAM), which prevents its recycling back into NAD+. By inhibiting this mechanism, 5-Amino-1MQ preserves the NAD+ salvage pathway. Research indicates that suppressing NNMT in animal models can significantly reduce white adipose tissue mass and body weight without altering food intake. It is currently a primary focus in studies involving metabolic syndrome, cellular senescence, and mitochondrial biogenesis.

Technical Specifications

Molecule Name: 5-Amino-1MQ
Synonyms: 5-amino-1-methylquinolinium iodide
CAS Number: 42464-96-0
Molecular Formula: C10H11N2+
Molar Mass: 159.21 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into 5-Amino-1MQ focuses on its disruption of the NNMT pathway:

NNMT Inhibition: Blocking NNMT prevents the clearance of NAM, directly increasing intracellular NAD+ levels and stimulating SIRT1 (sirtuin 1) activity.
Metabolic Shift: Elevated NAD+ levels lead to increased mitochondrial metabolism and energy expenditure in adipocytes.
Lipid Metabolism: Investigated for its ability to shrink white adipose tissue (WAT) and reduce cholesterol levels in vivo.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Avoid repeated freeze-thaw cycles.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 21 days for optimal experimental stability.
Handling: Standard laboratory safety protocols apply. Always wear protective gloves and eyewear. This product is for laboratory research use only.

Testing and Quality Control
At Flux Peptides, every batch of 5-Amino-1MQ undergoes:

HPLC (High-Performance Liquid Chromatography): Ensuring purity profiles exceed 99.0%.
MS (Mass Spectrometry): Verifying molecular weight and structure.
Stability Analysis: Confirming the compound remains potent under environmental stressors.

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