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Chemical Name: Retatrutide (LY3437943) Format: Lyophilized White Powder (Vial) Purity: ≥99% (Verified via HPLC & Mass Spectrometry) Sequence: Triple Agonist (GLP-1 / GIP / Glucagon Receptor)
Key Product Features:
Laboratory Grade: Synthesized strictly for in-vitro and analytical research.
Triple Mechanism: Unique interaction with GIP, GLP-1, and GCG receptors.
Quality Assured: Third-party Certificate of Analysis (COA) available upon request.
Stability: Nitrogen-purged and vacuum-sealed for maximum shelf stability.
⚠️ RESEARCH USE ONLY: This substance is intended for laboratory research purposes only. It is not approved by the FDA for human consumption, diagnostic, or therapeutic use.
Retatrutide is a synthetic peptide acting as a triple hormone receptor agonist. It is chemically designed to target and activate three specific receptors involved in metabolic regulation: the Glucose-Dependent Insulinotropic Polypeptide (GIP), Glucagon-Like Peptide-1 (GLP-1), and Glucagon (GCG) receptors.
Unlike dual agonists (such as Tirzepatide), the inclusion of the Glucagon receptor agonist in Retatrutide (LY3437943) is currently the subject of extensive Phase 3 clinical trials (e.g., the TRIUMPH studies) regarding its impact on hepatic lipid metabolism and energy expenditure.
Peptide Name: Retatrutide
Synonyms: LY-3437943, GGG Tri-agonist
CAS Number: 2381089-83-2
Molecular Formula: C221H342N62O64
Molar Mass: ~4731.33 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water (research solvents)
Research into LY3437943 focuses on its unique “GGG” synergy:
GLP-1 Agonism: Studied for its role in insulin secretion and delay of gastric emptying.
GIP Agonism: Investigated for its potential to improve insulin sensitivity and lipid buffering.
Glucagon (GCG) Agonism: The distinguishing factor of Retatrutide. In research settings, Glucagon agonism is observed for its ability to increase metabolic rate and promote lipolysis (fat breakdown) in the liver.
Lyophilized (Powder): Store at -20°C (freezer) for up to 36 months. Avoid repeated freeze-thaw cycles.
Reconstituted (Liquid): Once dissolved in a solvent, the solution should be kept at 4°C (refrigerated) and used within 2-3 weeks for optimal stability.
Handling: Always wear protective gloves and eyewear when handling research peptides.
We prioritize research integrity. Every batch of our Retatrutide is subjected to rigorous analytical testing:
HPLC (High-Performance Liquid Chromatography): To ensure purity exceeds 99%.
MS (Mass Spectrometry): To verify molecular weight and identity.
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