IGF-1 LR3 1mg

$80.00

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a highly potent synthetic analog of endogenous human IGF-1. Modified with an arginine substitution and a 13-amino acid extension, it effectively evades binding to IGF-binding proteins (IGFBPs). This 1mg format is heavily researched for its profound extended half-life and its capacity to induce severe cellular hyperplasia and accelerated muscle tissue synthesis in laboratory models.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Type 1 IGF Receptor (IGF1R)
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Cellular hyperplasia, muscle growth signaling, and glucose metabolism
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

IGF-1 LR3 Overview

IGF-1 LR3 is a chemically engineered, 83-amino acid analog of human Insulin-like Growth Factor-1. Native IGF-1 plays a primary role in childhood growth and continues to have anabolic effects in adults, mediating many of the functions of Growth Hormone (GH). However, endogenous IGF-1 is rapidly bound by IGF-binding proteins, rendering it inactive with a half-life of roughly 20 minutes. By substituting arginine for glutamic acid at position 3 and adding a 13-amino acid peptide extension at the N-terminus, IGF-1 LR3 bypasses these binding proteins. This modification extends its biological half-life in research models to 20-30 hours, allowing for sustained receptor activation. It is heavily utilized in studies focusing on cellular hyperplasia (the splitting and creation of new cells) rather than mere hypertrophy (cell enlargement).

Technical Specifications

Peptide Name: IGF-1 LR3
Synonyms: Long R3 IGF-1, Long Arg3 IGF-1
CAS Number: 143045-27-6
Molecular Formula: C400H625N111O115S6
Molar Mass: ~9111.6 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or specific dilute acid buffers (e.g., 0.6% acetic acid)

Mechanism of Action (Research Context)
Research into IGF-1 LR3 focuses on its intense anabolic signaling pathways:

Cellular Hyperplasia: Binds to the IGF-1 receptor (IGF1R) to trigger a cascade of intracellular signals that promote mitosis, generating entirely new muscle cells in vitro.
Nutrient Partitioning: Alters metabolic pathways by shuttling amino acids and glucose away from adipose tissue and directly into skeletal muscle tissue for protein synthesis.
Myogenesis & Repair: Investigated for its ability to rescue damaged tissue and prevent apoptosis (programmed cell death) during acute cellular stress.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 14-21 days.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of IGF-1 LR3 1mg undergoes:

HPLC (High-Performance Liquid Chromatography): Ensuring purity profiles consistently exceed 99.0%.
MS (Mass Spectrometry): Verifying the precise 83-amino acid structural modification.
Stability Analysis: Confirming the peptide maintains its integrity under controlled laboratory conditions.

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