Sermorelin 5mg

Description

Sermorelin Overview

Sermorelin (often prepared as Sermorelin Acetate) is a biologically active synthetic analog of naturally occurring Growth Hormone-Releasing Hormone (GHRH). Endogenous GHRH contains 44 amino acids, but research has proven that only the first 29 amino acids are necessary for robust pituitary stimulation. Our 5mg presentation is ideal for sustained research into the restoration of youthful hormonal axes. Unlike exogenous rHGH administration—which can suppress natural hormone production via negative feedback loops—Sermorelin works “upstream.” It actively stimulates the somatotrophs in the anterior pituitary to synthesize and release the subject’s own natural growth hormone. Research highlights its ability to respect the body’s natural somatostatin feedback loop, preventing unnatural hormonal flooding and preserving biological pulsatility.

Technical Specifications

• Peptide Name: Sermorelin
• Synonyms: GRF 1-29 NH2, Sermorelin Acetate
• CAS Number: 86168-78-7
• Molecular Formula: C149H246N44O42S
• Molar Mass: 3357.9 g/mol
• Purity: ≥99.0% (determined by HPLC)
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into Sermorelin centers on upstream endocrine modulation:

• Pituitary GHRH Agonism: Binds to GHRH receptors on pituitary somatotrophs, initiating a cAMP-dependent signaling cascade that results in the transcription and release of endogenous GH.
• Pulsatile Secretion: Maintains natural circadian rhythms of hormone release, making it highly valuable in chronobiology and sleep architecture studies.
• Neuroendocrine Axis Preservation: Prevents the pituitary atrophy often observed in studies utilizing long-term exogenous synthetic growth hormone administration.

Storage and Handling

• Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Protect from direct light.
• Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 14-21 days to prevent enzymatic degradation.
• Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of Sermorelin 5mg undergoes:

1. HPLC: Ensuring purity profiles consistently exceed 99.0%.
2. MS (Mass Spectrometry): Verifying the precise 29-amino acid fragment sequence.
3. Stability Analysis: Confirming the peptide maintains its functional capacity to stimulate GHRH receptors in vitro.