KPV 10mg

$50.00

KPV (Lysine-Proline-Valine) is a potent, naturally occurring tripeptide derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH). In laboratory settings, this 10mg format is heavily researched for its highly targeted anti-inflammatory and antimicrobial properties, particularly excelling in studies involving gastrointestinal health, mucosal healing, and chronic dermatological conditions.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Melanocortin Receptors and NF-κB pathways
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: Inflammatory bowel disease (IBD), mucosal integrity, and mast cell stabilization
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

KPV Overview

KPV is an ultra-short tripeptide (Lys-Pro-Val) that represents the core functional anti-inflammatory sequence of the larger α-MSH (alpha-melanocyte-stimulating hormone) molecule. However, unlike full-length α-MSH, KPV exerts profound immunomodulatory and anti-inflammatory effects without stimulating melanogenesis (skin pigmentation) or behavioral changes. Because of its small molecular weight and unique structure, KPV can easily penetrate cell membranes and interact directly with inflammatory signaling pathways deep within tissues. It is currently a premier subject of research in models of Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), mast cell activation, and inflammatory skin conditions like psoriasis and eczema.

Technical Specifications

Peptide Name: KPV
Synonyms: Lysyl-prolyl-valine, α-MSH (11-13)
CAS Number: 677279-00-2
Molecular Formula: C16H30N4O4
Molar Mass: 342.43 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into KPV highlights its remarkable ability to quell cellular inflammation at the source:

NF-κB Inhibition: Enters the cell and directly inhibits the activation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), fundamentally shutting down the transcription of pro-inflammatory cytokines.
Antimicrobial Properties: Demonstrates targeted antimicrobial and anti-fungal properties, particularly against specific pathogens that disrupt gut microbiota and mucosal linings.
Mast Cell Stabilization: Reduces the degranulation of mast cells, thereby limiting the release of histamines and other inflammatory mediators in allergic and autoimmune models.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months. Protect from direct light.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 14-21 days to prevent degradation.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of KPV 10mg undergoes:

HPLC: Ensuring purity profiles consistently exceed 99.0%.
MS (Mass Spectrometry): Verifying the precise tripeptide structure (Lysine-Proline-Valine).
Stability Analysis: Confirming the peptide maintains its integrity and anti-inflammatory potency.

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