Thymosin Alpha-1 10mg

$80.00

Thymosin Alpha-1 (TA1) is a 28-amino acid synthetic peptide identical to the naturally occurring immunomodulator produced by the thymus gland. In research settings, this highly concentrated 10mg format is heavily utilized to study the restoration of depressed immune systems. It profoundly regulates T-cell function, enhances innate immunity, and modulates cytokine production in models of infection and autoimmune distress.

Purity: ≥99.0% (HPLC Tested)
Receptor Targets: Toll-like receptors (TLRs) and T-cell signaling pathways
Format: Lyophilized Powder for Laboratory Research
Key Research Focus: T-cell maturation, immunomodulation, and viral resistance
Stability: Optimized for long-term storage at -20°C

Category: Peptides

Description

Thymosin Alpha-1 Overview

Thymosin Alpha-1 (TA1) is a pleiotropic peptide naturally secreted by the thymus gland, the master organ responsible for the maturation of the immune system. It was first isolated from thymus tissue in 1977 and has since become a foundational compound in immunological research. The 10mg bulk vial allows for sustained, multi-dose protocols in animal models studying immune senescence, viral pathology, and immunodeficiency. Unlike compounds that indiscriminately boost immune responses (which can trigger autoimmune cascades), TA1 acts as a smart modulator. It is heavily researched for its ability to upregulate the immune response when encountering pathogens, while simultaneously dampening hyper-inflammatory cytokine storms, restoring baseline immune homeostasis.

Technical Specifications

Peptide Name: Thymosin Alpha-1
Synonyms: TA1, Thymalfasin
CAS Number: 62304-98-7
Molecular Formula: C129H215N33O55
Molar Mass: ~3108.3 g/mol
Purity: ≥99.0% (determined by HPLC)
Appearance: White to off-white lyophilized powder
Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)
Research into Thymosin Alpha-1 highlights its systemic orchestration of the immune cascade:

T-Cell Maturation: Actively drives the differentiation and maturation of precursor cells into active CD4+ and CD8+ T-cells, drastically improving the body’s adaptive immune response.
Cytokine Modulation: Stimulates the production of critical pro-immune cytokines like Interleukin-2 (IL-2) and Interferon-gamma (IFN-γ) to combat intracellular pathogens.
Innate Immunity Activation: Engages Toll-like receptors (specifically TLR9) on dendritic cells, enhancing antigen presentation and the initial recognition of foreign threats.

Storage and Handling

Lyophilized (Powder): Store at -20°C (-4°F) for up to 36 months.
Reconstituted (Liquid): Keep at 4°C (39°F) and utilize within 21 days for optimal experimental stability.
Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only.

Testing and Quality Control
Every batch of Thymosin Alpha-1 10mg undergoes:

HPLC: Ensuring purity profiles consistently exceed 99.0%.
MS (Mass Spectrometry): Verifying the precise 28-amino acid sequence.
Stability Analysis: Confirming the peptide maintains its immunomodulatory potency under controlled laboratory conditions.

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