Melanotan 2

Description

Melanotan 2 (MT-2)

Melanotan 2 is a synthetic lactam-cyclic peptide analog of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed at the University of Arizona as a more stable and potent alternative to natural α-MSH for the study of skin pigmentation and photoprotection against ultraviolet (UV) radiation.

In Canadian research settings, Melanotan 2 is extensively studied for its high affinity for melanocortin receptors, specifically MC1, MC3, MC4, and MC5. Unlike its predecessor (Melanotan 1), MT-2 is noted for its ability to cross the blood-brain barrier and influence central nervous system functions, making it a critical tool for investigating appetite suppression, energy homeostasis, and sexual dysfunction in experimental models.

Technical Specifications

• Peptide Name: Melanotan 2 (MT-2)
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• CAS Number: 121062-08-6
• Molecular Formula: C50H69N15O9
• Molar Mass: 1024.18 g/mol
• Purity: ≥99.0% (determined by HPLC)
• Appearance: White lyophilized powder
• Solubility: Soluble in sterile water or bacteriostatic water

Mechanism of Action (Research Context)

• Research into Melanotan 2 focuses on its non-selective activation of the melanocortin system:
• Melanogenesis (MC1R): Activation of the MC1 receptor stimulates the production of eumelanin, the pigment responsible for skin darkening. Studies explore MT-2’s potential to induce tanning independently of UV exposure.
• Metabolic Regulation (MC4R): MT-2 is a potent agonist of the MC4 receptor, which is central to the regulation of food intake and energy expenditure. Research focuses on its role in reducing appetite and increasing metabolic rate.
• Sexual Function: Investigations suggest MT-2 influences sexual arousal and erectile function through its action on central melanocortin receptors, providing a pathway for studying libido-related disorders.
• Photoprotection: Research explores the ability of MT-2 to provide a “biological tan,” investigating its efficacy in reducing DNA damage caused by UV radiation in skin cells.

Storage and Handling

• Lyophilized (Powder): Store at -20°C (-4°F) for long-term stability (up to 36 months). MT-2 is remarkably stable but should be kept in a cool, dry place away from direct sunlight.
• Reconstituted (Liquid): Once dissolved in a research solvent, the solution should be kept at 4°C (39°F) and utilized within 21 days. For long-term liquid stability, avoid frequent agitation of the vial.
• Handling: Standard laboratory safety protocols apply. This product is for laboratory research use only and not for human consumption.

Testing and Quality Control
Flux Peptides provides the technical precision required for rigorous Canadian scientific inquiry. Every batch of Melanotan 2 undergoes:

1. HPLC (High-Performance Liquid Chromatography): To ensure purity levels consistently exceed 99.0%.
2. MS (Mass Spectrometry): To verify the exact cyclic molecular structure and mass.
3. Domestic Quality Check: Visual inspection of the lyophilized cake for ease of reconstitution and consistency